There are a couple conversations that contain heavy foreshadowing about Neo's role in the movies.
Choi: Hallelujah. You're my savior, man. My own personal Jesus Christ.
Neo: You get caught using that...
Choi: Yeah, I know. This never happened. You don't exist.
Choi: Something wrong, man? You look a little whiter than usual.
Neo: My computer, it... You ever have that feeling where you're not sure if you're awake or still dreaming?
Choi: Mm, all the time. It's called Mescaline. It's the only way to fly. Hey, it just sounds to me like you need to unplug, man.
Neo will end up saving humanity, acting as Choi's own personal Jesus Christ. When Choi says, "This never happened. You don't exist," his words end up ringing true as Neo drives by the place where he used to eat those good noodles, and he says that none of his memories actually happened. The "awake or still dreaming" refers to what will soon happen when he meets Morpheus, and of course Choi has no idea just how true Neo's "need to unplug" is.
Mr. Rhineheart: You have a problem with authority, Mr. Anderson. You believe that you are special, that somehow the rules do not apply to you.
Neo disrespects the Architect and, according to the Merovingian, has much less respect than his predecessors. Mr. Rhineheart has no idea just how special Neo is (in fact, so special that he is the only person in the Matrix who can be called the One), and of course Neo goes on to break just about every rule and law within the Matrix.
There are several lines throughout the movies that give us clues that Neo is significantly different from his five predecessors:
When Agent Smith opens up Thomas Anderson's criminal record in the beginning of M1, the following personal information can be read:
Neo: Neo's Opposite
Neo: Neo's Parallel
Neo: The Machine
Neo: Altered Consciousness
Neo: In Mobil Avenue
Neo: What Neo Changes
Neo: Neo Dies?
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